You may notice it first with coffee or water.
A faint metallic tang that toothpaste doesn’t erase.
This taste change has been reported by some long-term users.
It can reduce appetite or alter food enjoyment over time.
Many people assume it’s dental or age-related.
Yet once noticed, it’s hard to un-notice.
And wait, because appetite changes don’t always move in one direction.
8. Unexpected Appetite Shifts
Linda, 61, felt full quickly, then oddly hungry hours later.
Her hunger cues felt unpredictable and slightly off.
Metformin can influence insulin sensitivity and gut hormones.
This may subtly change how hunger and fullness feel.
It’s not dramatic, but it can be confusing.
Especially when weight changes don’t match effort.
Which leads us directly into the next experience.
7. Gradual, Unintended Weight Changes
Some people lose weight slowly without trying.
Others feel weight plateaus despite careful habits.
Metformin may influence how the body uses glucose and fat.
These changes are usually modest and gradual.
Because they’re slow, they’re often attributed to aging.
But noticing the timing can reveal useful context.
Now let’s shift to something you feel more than see.
6. Fatigue That Feels Different Than “Normal Tired”
This fatigue isn’t just end-of-day exhaustion.
It can feel like mental fog paired with heavy limbs.
Some research suggests metformin may affect vitamin B12 absorption.
Low B12 levels have been associated with fatigue and weakness.
Many people never connect the dots.
Until energy quietly keeps slipping.
And fatigue often brings company.
5. Tingling or Numbness in Hands and Feet
You may notice pins-and-needles sensations at night.
Or a dull numbness in toes that wasn’t there before.
This can have many causes, including circulation or posture.
Long-term metformin use has been linked to B12 deficiency in some cases.
Nerve sensations may appear gradually.
Making them easy to rationalize away.
But nerve signals aren’t the only quiet change.
4. Mood Shifts or Emotional Flatness
You may feel less reactive, less joyful, or oddly neutral.
Not sad, just muted.
Blood sugar stability can influence brain chemistry and mood.
Fatigue and nutrient changes may also play a role.
People rarely connect mood shifts to medication.
Yet emotional changes deserve as much attention as physical ones.
Now let’s talk about something most people never associate with medication.
3. Increased Sensitivity to Cold
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